intermembrane space

Biochemical and genetic evidence indicates that Bcl-2 blocks most forms of apoptosis by preventing mitochondrial changes , such as the release of cytochrome c and an apoptosis-inducing factor from the intermembrane space into the cytoplasm .

生物化学和基因方面的证据表明Bcl-2是通过抑制线粒体的变化来阻止细胞凋亡的，如抑制细胞色素C和凋亡诱导因子由膜间隙进入细胞浆等。

AIM : To explore the protein-protein interactions of human mitochondrial intermembrane space ( IMS ) and construct the protein-protein interaction map .

目的：以人源线粒体膜间隙内蛋白为主要研究对象，发掘它们之间的相互作用，构建其相互作用网络。

We analyzed the network and validated some interactions of the network with Co-IP and GST-pull down . The investigation is very important to better understand the function establishment of proteomics and the biological characters of intermembrane space proteins .

在此基础上，又对网络进行了分析，并对部分相互作用进行Co-IP、GST-PullDown等验证和深入研究，为更好地认识线粒体膜间隙蛋白质组的功能构建及生物学性质奠定了重要的基础。